A researcher wants to compare the precision of two different assays for the dete

Question

A researcher wants to compare the precision of two different assays for the determination of a tumor marker in blood serum. The researcher finds that one method gives a measured concentration of 20.45 ± 0.06 ng/mL for ten replicate measurements of the tumor marker. The second method gives a measured tumor marker concentration of 21.62 ± 0.13 ng/mL for ten replicate measurements of the same serum sample. Which of the following tests should the researcher use to determine if the precision of the two methods is within experimental error at a specific confidence interval? A. F Test B. Grubbs Test C. Paired T test

Explanation / Answer

F-test: It is used to decide whether two standard deviations are significantly different from each other.

Grubbs Test: It is used to decide whether or not a questionable datum should be discarded.

Paired T-test: It is used to find confidence interval and to compare mean values measured by different methods.

Since researcher use to determine if the precision of the two methods is within experimental error at a specific confidence interval, the useful test is F-test.

Therefore, the correct option is A. F-test.

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