Which of the following statements about diseases related to carbohydrate metabol

Question

Which of the following statements about diseases related to carbohydrate metabolism is False? Select one: a. Galactokinase deficiency causes increased [Galactose] in blood and urine b. Glucose can be converted in to Fructose using Sorbitol as an intermediate in the presence of Sorbitol dehydrogenase. Low levels of Sorbitol Dehydrogenase in the cells of the retina, and lens results in cell swelling. c. Aldolase reductase converts Glucose in to Sorbitol and Galactose in to Galacititol. High levels of both these products could release to cataracts. d. Classic Galactosemia results in accumulation of Galactose 1-P in the liver, brain, and eyes. Which of the following statements about Ca+2 (secondary messenger) is False? Select one: a. Increasing [Ca+2] increases activity of Phosphorylase Kinase b. Increasing [Ca+2] increases activity of Calmodulin dependent protein kinase c. Increasing [Ca+2] increases activity of Glycogen Synthase d. Increasing [Ca+2] increases activity of PDH phosphatase

Explanation / Answer

1.D In classic galactosemia, due to deficiency of Galactose 1-P , Galacititol is produced which gets accumulated in liver, brain and eyes and not Galactose 1-P is accumulated.

2.C there is no big effect of Ca++ on Glycogen synthase

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