Exercise 1: Comparison of NSAIDs Data Table 1. Comparison of Common NSAIDs. Gene
ID: 1005803 • Letter: E
Question
Exercise 1: Comparison of NSAIDs
Data Table 1. Comparison of Common NSAIDs.
Generic name
Commercial brand name(s)
Prescription only
Typical uses
Enzymes
inhibited
Source(s)
Meloxicam
Mobic
x
Reduce pain and swelling associated with osteoarthritis and
rheumatoid arthritis
COX-1 & COX 2
Indicate your resources here
Aspirin
Naproxen
Ibuprofen
Celecoxib
Diclofenac
Questions
Define the acronym NSAID. Why are NSAIDs valuable to medicine?
What property of aspirin makes it unique among the NSAIDs?
Define the roles of the cyclooxygenase enzyme and prostaglandins in the body. What types of stimuli prompt the production of the two forms of the cyclooxygenase enzyme?
How do NSAIDS work to block pain?
In Data Table 1, which NSAIDs are selective for COX-2?
According to Data Table 1, what are some ailments that all of the NSAIDs treat?
Identify four general properties that make an NSAID unique as compared to the NSAID aspirin. List specific properties that make aspirin, naproxen, and ibuprofen unique from one another.
Generic name
Commercial brand name(s)
Prescription only
Typical uses
Enzymes
inhibited
Source(s)
Meloxicam
Mobic
x
Reduce pain and swelling associated with osteoarthritis and
rheumatoid arthritis
COX-1 & COX 2
Indicate your resources here
Aspirin
Naproxen
Ibuprofen
Celecoxib
Diclofenac
Explanation / Answer
Q.1: NSAID stands for nonsteroidal anti-inflammatory drug. NSAIDs are a class of drugs that provide both analgesic and antipyretic effect along with anti-inflammatory effect at higher dose. These are valuable medicines because they provide both analgesic and antipyretic effect along with anti-inflammatory effect at higher dose.
Q.2:Aspirin is unique among NSAIDS because it has many functions like analgesic, antipyretic and anti-inflammatory. It is also effective in curing heart attack thrugh its beneficial effect on cardiovascular system.
Q.3: Cyclooxygenase(COX) enzyme stimulates the formation of prostaglandins and prstanoids. Hence the pharmacological inhibition of Cyclooxygenase enzyme gives releif from inflammation and pain. NSAID drugs exert their effect through the inhibition of COX.
Prostaglandin is responsible for inflammation to infection and injury in response to immune system.
Cyclooxygenase(COX) is produced in response to injury infection etc.
Q.4: NSAID drugs inhibit the enzymes cyclooxygenase-1 and cyclooxygenase-2 that are responsible for the production of prostaglandin in a reversible way. Since prostaglandin stimulates inflammation during injury and infectin.
Q.5: NSAIDs selective only for COX-2 is celecoxib. The rest of the drugs are selective for both COX-1 and COX-2.
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