In a mutant mouse, NO synthase is mutated to show a dominant negative phenotype

Question

In a mutant mouse, NO synthase is mutated to show a dominant negative phenotype in the background of a mutation that negatively affects the nitrite production by mitochondria. From the choices below, choose the best strategy to treat the mutant phenotype. Overexpress Adenylyl cyclase to increase production of cAMP. Treat the mouse with nitroglycerine to increase production of NO. Reduce expression of Guanylyl cyclase to decrease production of cGMP. Treat the mouse with a chemical that inhibits Phosphodiesterase. Treat mouse with intravenously supplied membrane permeable cGMP complex.

Explanation / Answer

Nitric Oxide produces largely from enzymatic pathways and lesser by a non-enzymatic pathway occurring via lungs. Nitric Oxide synthase (NOS) is the enzyme that produces Nitric Oxide through enzymatic pathways. Therefore, if NOS mutated and negatively affects the NO production, we have to increase the production of NO by using chemical like nitroglycerin. That will overcome the negative effect of mutant NOS genes.

Therefore, the second option is correct.

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