A secondary messenger molecule \'A\' interacts in a cooperative fashion with a m

Question

A secondary messenger molecule 'A' interacts in a cooperative fashion with a molecule 'B. Cooperative binding of 4 molecules of A activates B. Two molecules of B interact with a second molecule 'C, in a cooperative manner to activate C. The activity of C as an effector of the signaling pathway is plotted in a histogram. Choose which of the plots (1,2,4,8) would be the correct plot to reveal activity profile of C (Y-axis) in response to increasing concentration of the secondary molecule 'A' (X axis). -1 molecule -2 molecules -4 molecules -8 molecules 10 10 10 0 10 Conc (secondary messenger) 0 2 0 4 O 8

Explanation / Answer

1) Four molecules of A are required to activate 1 molecule of B. Then, 2 molecules of B are required to activate 1 molecule of C. Effectively, we need 8 molecules of A to activate 1 molecule of C. Therefore, the correct activity plot of the molecule C will be of 8 molecules of A on X axis and C on Y axis.

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