Sodium 2-propylpentanoate (an alkyl carboxylate) is a drug that is used to treat

Question

Sodium 2-propylpentanoate (an alkyl carboxylate) is a drug that is used to treat epilepsy. For some individuals, sodium 2-propylpentanoate is toxic, which might result from the formation of toxic metabolites in the liver. 2-Propylpentanoate and its metabolites are detected in liver extracts using mass spectrometry to investigate the mechanism of its toxicity so that epilepsy treatment can be improved. The accurate mass-to-charge ratio (m/z) of the 2-propylpentanoate ion is 159.13905. During the liquid chromatography mass spectrometry experiment, a co-eluting endogenous liver metabolite ion elutes with the same retention time and has an accurate m/z value of 159.13510. What is the minimum resolving power that is required to detect both 2-propylpentanoate and the endogenous metabolite ion as separate peaks? b. Name two common mass analyzers that will give you the best chance of resolving these two ions.

Explanation / Answer

a)Minimum resolving power =m1/m where m1 is lower m/z value

Therefore res power = 159.13510/(159.13905-159.13510)=40287.36709

b) quadrapole mass analyzer

Time of flight mass analyzer

Ion cyclotron resonance

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