Anita is a graduate student in a lab studying role of BMP signaling in bone deve

Question

Anita is a graduate student in a lab studying role of BMP signaling in bone development. She has obtained a mutant mice line in which the BMP signaling is impaired (reduced). Using antibody staining, she has identified that BMP ligands interacts with Type II receptors leading to phosphorylation of Type II receptors. In a western blot analysis, she found that R-SMAD was not phosphorylated. Choose the statement that best describes the cause of this phenotype.

C)

Explanation / Answer

The option B is correct.The phosphorylation of R-SMAD is done directly by the type I receptor through the kinase present intracellularly. This leads to the activation of the R-SMAD activation. As the BMP signaling is impaired, the Type I receptors does not function properly due to which the phosphorylation does not take place.

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