Complete the reaction for the biosynthesis of thymidine monophosphate (dTMP) fro

Question

Complete the reaction for the biosynthesis of thymidine monophosphate (dTMP) from the substrate and the coenzyme N^5,N^10 -methylenetetrahydrofolate (5,10-methylene-THF). + 5,10-Methylene-THF rightarrow dTMP + Select the three true statements. The enzyme that catalyzes this reaction is a target for the treatment of cancer. This reaction is catalyzed by thymidylate synthase. 5,10-methylene-THF must be regenerated from DHF in order to continue to produce dTMP. The sole purpose of 5,10-methylene-THF is to donate hydrogen atoms. This reaction is part of all three salvage synthesis pathways of dTTP.

Explanation / Answer

Answer:

The following reaction is catalyzed by thymidylate synthetase:

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.

1. 5,10- methylene-THF is used in treatment cancer along with flurouracil.

2.this reaction catalysed by thymidylate synthase.

3. 5,10-methylene-THF must be regenerated from DHF in order to continue to produce DTMP.

These three are correct.

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