In cytokine signaling, JAK activity is required to initiate the cascade of signa

ID: 101029 • Letter: I

Question

In cytokine signaling, JAK activity is required to initiate the cascade of signaling. When Socs2 is knocked out in mice, the mutant mice appear to show gigantism. In an attempt to rescue (change it to wild type) the phenotype, a student adds a chemical in the diet of the mouse, which specifically prevents phosphorylation of STAT in the mouse.

What do you expect to see as a result of this experiment?

The mutant mouse (Socs2-/-) does not show any change in appearance or activity of cytokine signaling pathway

Explanation / Answer

The JAK/STAT signalling pathway transmits information from the extracellular signal to the nucleus resulting in cellular proliferation. When this pathway is affected, it results in uncontrolled proliferation of cells causing cancer and immune disorders. Therefore, when the phosphorylation of STAT is prevented, the growth of the mutant mouse will be controlled, accompanied by reduced activation of cytokine signalling. So, the correct answer for this question is option b.

Navigate

In current C++ when body of if statements contain only one command then: Parenth

In data mining, we must construct a fixed-length feature vector representation f

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.

In cytokine signaling, JAK activity is required to initiate the cascade of signa

Question

Explanation / Answer

Related Questions

Navigate