Complete the following questions using short answers, diagrams, etc. Write answe

Question

Complete the following questions using short answers, diagrams, etc. Write answers directly on the test packet. You are testing the effects of drugs on a somatic neuron. Adding epinephrine to the dendrites generates an EPSP (via influx of calcium ions), leading to action potential, and ACh release at the axon terminal. This neuron is a somatic neuron attached to skeletal muscle. Describe the effect in each of the following cases on the neurons (ie- EPSP, AP, NT release, contraction)? (a) What is the effect of adding a drug that blocks voltage-gated Ca2^+ -channels? (b) What is the effect of adding a drug that blocks calcium release from the sarcoplasmic reticulum. (c) What kind of drug would give you EPSP, No AP, and No ACh release when stimulating with epinephrine? In other words, what could the drug block?

Explanation / Answer

a) The drug which blocks the voltage gated calcium channels will prevent the entry of calcium ions into the terminal bouton of axon terminal. This will block the release of neurotransmitter and muscle contraction.

b) The drug which blocks the release of calcium ions from the sarcoplasmic reticulum prevents the binding of actin with myosin. Therefore, this drug blocks muscular contraction.

c) The drug which causes EPSP, but no AP and no ACh release would have probably blocked sodium channels preventing depolarization of nerve membrane necessary for the development of action potential. As no action potential is generated, ACh release is also blocked.

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