5. Describe the role of the five coenzymes (cofactors) in the pyruvate dehydroge

Question

5. Describe the role of the five coenzymes (cofactors) in the pyruvate dehydrogenase complex. 6. How much ATP is generated when one molecule of glucose is converted to two molecules of lactate? 5. Describe the role of the five coenzymes (cofactors) in the pyruvate dehydrogenase complex. 6. How much ATP is generated when one molecule of glucose is converted to two molecules of lactate? 5. Describe the role of the five coenzymes (cofactors) in the pyruvate dehydrogenase complex. 6. How much ATP is generated when one molecule of glucose is converted to two molecules of lactate?

Explanation / Answer

5. Pyruvate dehydrogenase complex (PDH complex):

PDH complex is multienzyme complex containing of: 3 enzymes+ 5 coenzymes + other proteins

Enzymes:

Coenzymes(Cofactors):

Roles of coenzymes of PDH complex:

Thiamine pyrophosphate (TPP):

Lipoic Acid:

FAD and NAD+

Coenzyme A(CoA-SH)

6. In homolactic fermentation, one molecule of glucose is ultimately converted to two molecules of lactic acid

that is this much of energy generated i.e, enthalpy change during formation is -1273.3 KJ/mol

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