Based on the alternate pathway given above, would you expect regulation of this

Question

Based on the alternate pathway given above, would you expect regulation of this pathyway to be the same as glyolysis? why or why not?

Most facultative anaerobic organisms that produce ethanol as a product use the glycolysis pathway followed by alcohol fermentation to produce ATP from glucose. The laboratory you work for has discovered an organism called E. hugdahlis that uses several reactions not found in the typical glycolysis pathway (reaction 1. reaction 2, and reaction 3 on the figure below), Only the three specified reactions utilize new enzymes, all other reactions utilize identical enzymes to typical glycolysis and alcohol fermentation. The new pathway is shown below H+OH reaction 2 20 reaction 1 HOTH NAD NADH ATP ADP CH2OPO3 2-keto-3-deary 2- CH2OPO reaction 3 NAD" NADH CO2 acetaidehyde ethanol pyruvate CO2 NAD NADH .._ acetaldehyde- ethanol pyruvate - glyceraldehyde 3phosphate

Explanation / Answer

No, it cannot regulate as mammalian glycolytic pathway. That is because of two reasons, the formation of Fructose 1,6-bisphosphate does not occur in the reaction. In mammalian glycolytic pathway it regulated through phophofructokinase and Fructose 1,6-bisphosphatase. On the other hand, there is no phoshpoenol pyruvate formed.

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