In response to the hormone epinephrine cyclic AMP levels increase and the enzyme

Question

In response to the hormone epinephrine cyclic AMP levels increase and the enzyme glycogen

phosphorylase is activated. Which of the following best describes the sequence of events.

A.Protein Kinase A is allosterically activated, which then activates glycogen phosphorylase by

phosphorylation.

B.Protein Kinase A is allosterically repressed, which then activates glycogen phosphorylase by phosphorylation.

C.Protein Kinase A is allosterically activated, which then activates glycogen phosphorylase by

removal of a phosphate group.

D.Protein Kinase A is allosterically repressed, which then activates glycogen phosphorylase by

removal of a phosphate group.

E.The cAMP affects glycogen phosphorylase directly by allosteric activation.

Explanation / Answer

answer is A. Protein Kinase A is allosterically activated, which then activates glycogen phosphorylase by

phosphorylation.

Protein kinase A (PKA) is allosterically activeted by cyclic AMP .  the glcogen phospholase is converted from a low-activity form into a high-activity one by phosphorylation of its subunit. The enzyme catalyzing the activation of phosphorylase kinase is protein kinase A (PKA), which is switched on by a second messenger, cyclic AMP

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