*Genetics-based Question* 1. A breeder of Irish setters has a particularly valua
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Question
*Genetics-based Question*
1. A breeder of Irish setters has a particularly valuable male show dog descended from a famous female named Rheona Didona who was known to carry a harmful recessive gene for blindness caused by atrophy of the retina. Before she breeds the dog, she wants some assurance that it does not carry this harmful allele. However, there is no molecular test available for the disease, and you do not have the time to develop a new one. What strategy do you suggest to test the dog?
Explanation / Answer
A breeder of Irish setters has a particularly valuable male show dog descended from a famous female named Rheona Didona who was known to carry a harmful recessive gene for blindness caused by atrophy of the retina. Before she breeds the dog, she wants some assurance that it does not carry this harmful allele. However, there is no molecular test available for the disease, and you do not have the time to develop a new one.
Therefore, the breeder be supposed to testcross the male to a female with retinal atrophy. The appearance of mutant pups would signify the male dog was a heterozygous carrier. If no mutant pups come out in several liters. It is unlikely that the male carries the harmful allele.
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