Suppression of a nonsense mutation involves a change in nucleotide sequence of a
ID: 1025994 • Letter: S
Question
Suppression of a nonsense mutation involves a change in nucleotide sequence of a tRNA molecule.
What part of the tRNA molecule is changed?
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Correct- tRNA anticodon was correct answer
Part B How might this affect translation globally within a cell?
This would result in early termination of translation in the place where the codon to the tRNA occur.
This would result in replacement of the amino acid coded by the original tRNA with another.
This would not affect translation globally within the cell because the amount of tRNAs is excessive.
This would result in addition of an excessive amino acid to the C' end and termination failure.
the D-loop the acceptor stem the TC-loop the tRNA anticodonExplanation / Answer
Answer: This would result in addition of an excessive amino acid to the C' end and termination failure.
Reason: A nonsense mutation occurs when a sense codon, one that codes for an amino acid, is changed to a chaintermination codon, UAG, UAA or UGA. A simple mutation in the anticodon of a tRNA moleculae can change its coding specificity, and in specific cases allow the "reading" of stop codons as sense codons. When the new anticodon corresponds to a termination codon, an amino acid is inserted and the polypeptide chain is extended beyond the termination codon. This results in nonsense suppression at a site of nonsense mutation or in readthrough at a natural termination codon. A nonsense suppressor is a gene coding for a mutant tRNA able to respond to one or more of the termination codons and insert an amino acid at that site. The suppressor mutation creates an aminoacyl-tRNA that can recognize the termination codon; by inserting an amino acid, it allows protein synthesis to continue beyond the site of nonsense mutation.
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