How do you do this? What is the Pka for Triazole? 5.14 Tos. Discr. 5.17 in a tos

Question

How do you do this? What is the Pka for Triazole?

5.14 Tos. Discr. 5.17 in a toss of at is probability * the proba 5.21 in couples where of 0.25 that any child of the any child will not have the disea parents are heterozygotes, find the prot is he avilla á. none of the 6 children or a 2. Acy 1,2,4 triazoles can be synthesized via a nucleophilic acyl substitution reaction using sodium azide and several different carboxylic acid derivatives. 0 Na N-N + N FN RN-N RX Sodium 1,2,4 Triazole Acyl 1,2,4 Triazole Answer the following questions about the formation and reactivity of acyl 1,2,4 triazoles. A) Describe the relative reactivity of acyl 1,2,4 triazoles by comparing them to acid chlorides anhydrides, esters, and amides. Explain how you determined this order of reactivity bei sure to use correct general chemistry and organic chemistry terms.

Explanation / Answer

Relative reactivity

The relative reactivity of acyl-1,2,4-triazole is greater than the reactivity of acid chloride. In acyl-1,2,4-tiazole, the resulting N- species formed after the loss of acyl substituent is stabilized by resonance with the double bonds in the molecule. This makes the forward reaction more favorable and faster loss of acyl group occurs. Whereas, in case of acid chloride, the stabilization of Cl-, the leaving group after departure is not that effective when compared to the triazole ring system, therefore, the reactivity of acid chloride is lower then the acyl-1,2-4-triazole.

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