12. What reaction does pyruvate kinase catalyze? 13. Understand the key role of

Question

12. What reaction does pyruvate kinase catalyze?

13. Understand the key role of the central metabolite pyruvate. What are the possible fates of pyruvate after glycolysis?

14. Compare and contrast respiration and fermentation. What is the “purpose” of fermentation? What are the 2 ways that NADH is oxidized for further use in glycolysis?

15. What is the purpose of lactic acid fermentation? What are the consequences of lactate build-up in muscle cells? How is lactic acid removed from the muscle cell?

16. How is dietary fructose metabolized in adipose tissue? In the liver? What is the problem with a high dietary consumption of fructose in terms of liver metabolism? (Hint: phosphofructokinase)

17. Know the 3 enzymes that catalyze the irreversible reactions in glycolysis and are thus under regulatory control. What is the key regulator of glycolysis?

18. Know the allosteric regulators of phosphofructokinase (PFK) in both the muscle and the liver. Why is AMP rather than ADP the signal for low-energy state? What is the significance of citrate? What role does the metabolite fructose 2,6-bisphosphate play in allosteric control of PFK in the liver?

19. How is hexokinase regulated? Why is PFK rather than hexokinase considered to be the primary regulator of glycolysis?

20. Why is glycolysis regulation in the liver more complex than in muscle?

Explanation / Answer

Ans 12 :

Pyruvate kinase is an important enzyme , that has its four isozymes in vertebrates.

Pyruvate kinase catalyzes the last step of glycolysis It transfers the phosphate group from phosphoenolpyruvate to ADP generating pyruvate and ATP.

Related Questions

Navigate

• Browse (All)
• Browse 1
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.