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Soh xMypresentationsxhtpe/prei.comXCoure Course Homex n Soft. house.com/pluginfile.php/544262/mod resource content/ 1/Prelab%20%20Synthess%20of%20aspinn.pdf Pre-lab Assignment: Synthesis of Aspirin 1. What is the chemical name for aspirin? 2. How does aspirin work in the human body? 3. What is the name of the compound that was isolated from the bark of the willow and had a similar effect as aspirin? 4, what is a common side effect of the compound from #4? 5. Draw and label the complete setup to perform vacuum filtration. 6. What is the theoretical yield for aspirin if you start with 3 g of salicylic acid and 3 g of acetic anhydride?

Explanation / Answer

1. The chemical name of aspirin is acetylsalicylic acid.

2. Aspirin acts as an analgesic (fever and inflammation suppressing agent) by inhibiting irreversibly the enzymes called cyclooxygenases (COX) which are responsible for the synthesis of prostaglandins which are responsible for fever, etc. Aspirin has an acetyl group with which it acetylates irreversibly COX thus inhibiting the enzymatic activity when it binds to these COX.

3. Though willow bark also contained acetylsalicyate, its major ingredient was salicylic acid along with other similar salicylates.

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