the reaction shown in egn 3 occurs instantaneously. Thus, all of the p chemicals
ID: 1039257 • Letter: T
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the reaction shown in egn 3 occurs instantaneously. Thus, all of the p chemicals that are used in this reaction must be completely dry (an under anhyedrous conditions In the presence of even weak acids (e.s RMgX + HOH -_? RH + Mg(011)X While Grignard reagents are also good nucleophiles and in some cases MgOH)X (3) can react with the starting orgamic halide to give a coupling product as shown in eqn 4ce have shown that radicals (R.) are formed R-R+ MgX (4) during the preparation of the Grignard reagent. Thus, this coupling product ormed by the combination of two radicals, as shown in egn 5. In any case, the ht al b R.+R concentration of RX in reaction mixture is allowed to get too high. Because of the relaeygh the C-Mg bond, Grignard reagents are readily oxidized by air to peroxide anio formation of this by-product (R-R) becomes important if the conce te shown in eqn 6. Thus, these reagents cannot be stored easily and must be used preparation Organic chemists take advantage of the reactivity of Grignard reagents with yde to give primary alcohols, the differences in the structures of the two tertiary alcohols that are produced in reactions carbonyl compounds to synthesize alcohols (primary, secondary, and tertiary) and carboxylic acids. The type of alcohol formed is a function of the type of carbonyl compound used. Grignard reagents react: () with formaldehyde to give primary alcoho egn 7; () with any other aldehyde to give secondary alcohols, eqn 8; (ii) with kne to give tertiary alcohols, eqn 9; and (iv) with esters to give tertiary alcohols, egn l 0. (Note 9 and 10). Grignard reagents also react with carbon dioxide to give carboxylic acids, eq 174Explanation / Answer
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