9. (7 pts) Complete the statement below regarding regulation of the glycolytic p
ID: 1040052 • Letter: 9
Question
9. (7 pts) Complete the statement below regarding regulation of the glycolytic pathway. The enzyme which catalyzes the committed step of glycolysis is of this reaction is choice) ? The product and this activates or inhibits (CIRCLE CORRECT (name of a glycolytic enzyme). 1o. The enzyme glycogen phosphorylase sequentially removes glucose residues from a glycogen polymer. a. (2pt) What substrate (other than glycogen) is required by this enzyme? b. (2pts) What is the product of this reaction, aside from modified glycogen? 11. a. (2 pts) What is the ?0" for the reaction below at 25 °C, given that the AG for ATP hydrolysis to ADP is-30.5 kJ/mol and the AGo for the hydrolysis of glycerol 3 phosphate to glycerol is-13.8 kJ/mol at 25 °C. glycerol 3-phosphate + ADPg glycerol+ATP b. (3pts) Calculate the equilibrium constant (at 25 °C) for the reaction shown above. 12. (6 pts) The metabolism of fructose and glucose in muscle are basically identical, whereas in the liver, there are some differences. a. (2 pts) Explain, in one sentence, why fructose metabolism differs from glucose in the liver b. Is one difference between fructose and glucose oxidation in the liver related to the net energy (ATP) produced? Explain, in one or two sentences. (2 pts) c. What important step of glycolysis is bypassed by fructose when it is oxidized in the liver? Answer this question by writing the name of the enzyme that catalyzes this step. (2 pts)Explanation / Answer
Ans 9 :
Th enzyme which catalyze the committed step of glycolysis is Phosphofructokinase -1 (PFK-1) .
The product of this reaction is Fructose-1,6-biphosphate and this inhibits the Phosphofructokinase.
The enzyme PFK-1 catalyzes the most committed step of glycolysis , that gives pyuvate and ATP as the major products.
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