Q2-relationship between pH ,Pka and solubility? Q3-Arrangement from highest to l

Question

Q2-relationship between pH ,Pka and solubility? Q3-Arrangement from highest to lowest according bioavailability? Q4-why can’t take amoxicillin IV? Q5- mcq (choose one only) Pharmaceutics-II (PH 312) activity (10 marks) Question 1 (3 marks) The concentration of steroid remaining in transdermal patch is as follows: t (h) 30 60 90 120 150 Amount (ug) 164 128 92 5.6 What is the rate constant? Question 2 (3 marks) What is the relationship between pH, pKa, and solubility? Question 3 (1.5 marks) Depending on the type of the dosage form, a reduction in bioavailability might be seen. Rank the following dosage forms from the highest to the lowest order according to their b. c. Aqueous solution Solid dosage forms such as tablets and capsules Question 4 (1.5 marks) Why is there no pre-made liquid dosage form for IV amoxicillin formulation? Question 5 (1 marks) Which of the following excipients may be used to limit the presence of microorganisms in a sterile dosage form? a. Purified water b. Sodium lauryl sulphate c. Benzalkonium chloride d. Ascorbic acid

Explanation / Answer

1. Here, the concentration of steroid decreases linearly with time.

Therefore, the order of reaction with respect to the steroid = 0

The rate constant of the reaction (k) = ([Steroid]0 - [Steroid]t)/t

Where [Steroid]0 = The concentration of steroid at t = 0 and [Steroid]t = concentration of steroid at t = 30 h (let's say)

i.e. k = (20-16.4) ug/30 h

i.e. k = 1.2*10-1 ug/h

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