24. Which of the following best explains why an enzyme hasn\'t evolved to cataly

Question

24. Which of the following best explains why an enzyme hasn't evolved to catalyze the following reaction as the first step of glycolysis?

glucose +  inorganic phosphate à  glucose-6-phosphate

a. The use of ATP is required for this step to serve as a regulatory control point.

b. The use of ATP is important because it helps keep the concentration low. Otherwise the high [ATP] would slow glycolysis too much through feedback inhibition.

c. The large positive G' of this reaction would need to be overcome by an exceedingly high [Pi].

d. What are you talking about? That's exactly what does happen.

Explanation / Answer

regulatory control in the reaction is during the PFK step

ATP keeps the G6P at right amount and hence A is not correct

high delta G means endothermic reactino. So endothermic reaction requires a highly exergonic reaction for driving the reaction.

So C is correct

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