Which of the following two amides will react more readily with a nucleophile and
ID: 1055017 • Letter: W
Question
Which of the following two amides will react more readily with a nucleophile and why? 1, becaUse it is less hindered. 2, becaUse it is less hindered. 1, becaUse it is more strained. 2, becaUse it is more strained. They have similar reactivities, becaUse they do not have any major difference. What are the three steps in the acetoacetate synthesis, listed in the correct order? Alkylation, reduction, hydrolysis/decarboxylation. Hydrogenation, alkylation, deprotonation Alkylation, hydrolysis/decarboxylation, hydrogenation Hydrolysis/decarboxylation, deprotonation, alkylation Deprotonation, alkylation, hydrolysis/decarboxylationExplanation / Answer
a cyclic compound offer more steric hindrance as nucleophile can't attack from the side containing ring
So, 2 will react more readily as it is less hindered
Answer: B
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