The oxidized intermediate undergoes phosphorolysis and is released as 1,3-bispho

Question

The oxidized intermediate undergoes phosphorolysis and is released as 1,3-bisphosphoglycerate. The production of ATP in the next step of glycolysis requires a high-energy compound (such as 1,3-bisphosphoglycerate) as a substrate. How is the high-energy compound 1,3-bisphosphoglycerate produced in the glyceraldehyde 3-phosphate dehydrogenase reaction, which is close to equilibrium (?G° = 6.2 kJ/mol)? Select all that apply.

c) The oxidized intermediate undergoes phosphorolysis and is released as 1,3-bisphosphoglycerate. The production of ATP in the next step of glycolysis requires a high-energy compound (such as 1,3-bisphosphoglycerate) as a substrate. How is the high-energy compound 1,3-bisphosphoglycerate produced in the glyceraldehyde 3-phosphate dehydrogenase reaction, which is close to equilibrium (AG E 6.2 kJ/mol)? Select all that apply The thioester intermediate is a high-energy compound that "traps" some energy from the oxidation of glyceraldehyde 3-phosphate and enables phosphorylation. The oxidation of the aldehyde is strongly exergonic. ATP is hydrolyzed to provide Pi and energy for the reaction The reaction produces a reduced cofactor that can supply energy for the phosphorylation step

Explanation / Answer

The thioester intermediate is a high-energy compound that "traps" some energy from the oxidation of glyceraldehyde 3-phosphate and enables phosphorylation. The oxidation of the aldehyde is strongly exergonic.

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