PRPP can be used for the synthesis of which nucleotide? a.) adenosine 5’phosphat
ID: 10637 • Letter: P
Question
PRPP can be used for the synthesis of which nucleotide?
a.) adenosine 5’phosphate
b.) guanosine 5’phosphate
c.) cytidine 5’phosphate
d.) uridine 5’phopshate
e.) all of the above (I believe all?)
ATP is an excellent source of energy for AMP biosynthesis.
a.) True
b.) False
(I think False?)
Fluoro-dUMP is an excellent chemical for chemotheraphy because:
a.) dTMP is a product of this reaction and dTMP is only required for DNA biosynthesis
b.) DNA biosynthesis only occurs in mitotically or meiotically active cells
c.) Fluoro-dUMP is an effective inhibitor of thymidylate synthetase
d.) thymidylate synthetase is required for dTMP biosynthesis
e.) all of the above
(not sure about this one...)
please provide explanation if you can so I can understand thank you!
Explanation / Answer
1.PRPP is used for the synthesis of purines.another fact is that for the synthesis of purines activated form of ribose 5-phosphate is needed becuase the purine ring strucutres are synthesised on the ribose 5 phosphate.the ribose 5-phosphate reacts with ATP and forms PRPP.during synthesis the ribose phosphate part of PRPP gets transferred to purine to form the corresponding purine nucleotide. but another fact is that PRPP is also required for the synthesis of pyrimidines as the sugar moiety is supplied by PRPP. so the opiton is e. 2.the answer is false.because for the synthesis of AMP, GTP is the major source of energy. 3.the answer is c.one reason is that Thymidylate synthase is a target enzyme in anticancer.
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