QUESTION 1 For each characteristic of fatty acid metabolism listed below, fill i

Question

QUESTION 1

For each characteristic of fatty acid metabolism listed below, fill in the blank with whether it best describes:   

A= Fatty acid degradation

B= Fatty acid synthesis

C= Neither process

Occurs mostly in the cytoplasm _______

A methylene group is converted to a keto group _______

4-step reaction cycle is condensation, reduction, dehydration, reduction ______

Generates FADH2 ______

QUESTION 2

You are studying fatty acid metabolism in a strain of mice that is being fed a diet with very low amounts of carnitine. What impact would you expect this diet to have on fatty acid metabolism (either on FA synthesis or degradation) in the mice? Why?

QUESTION 3

You are studying fatty acid metabolism in a strain of mice that is transgenic for a mutation that disrupts the citrate binding site on acetyl CoA carboxylase I. What impact would you expect this mutation to have on fatty acid metabolism (either on FA synthesis or degradation) in the mice? Why

QUESTION 4

Now you are examining the adaptive control of fatty acid metabolism in mice. For each situation below fill in the blank with what effect you would expect to see on fatty acid metabolism where:

A= increase FA synthesis

B= decrease FA synthesis

C= increase FA degradation

D= decrease FA degradation

Transgenic mice overexpress SREBP1c ________

Transgenic mice overexpress PPAR _______

Transgenic mice have mutation to prevent ligand binding to PPAR ________

QUESTION 5

For each of the situations listed below determine the effect on cholesterol synthesis and fill in the blank where: A= increase cholesterol synthesis

B= decrease cholesterol synthesis

SREBP2 is highly resistant to proteolytic cleavage _______

HMG-CoA reductase is resistant to phosphorylation _______

QUESTION 7

How would you expect each of the following situations to affect cholesterol levels in the blood? Fill in the blank where: A= increase cholesterol levels

B= decrease cholesterol levels

C= no effect on cholesterol levels

Decrease expression of LDL receptor _______

Increased amount of HDL _______

Patient is taking a statin ________

QUESTION 6

In the sentence below fill in the blanks to indicate the correct function of certain lipoproteins.

____________ is the major carrier of cholesterol in the blood used to transport cholesterol to the tissues, whereas ________ transports excess cholesterol from the tissues back to the liver.

Explanation / Answer

Q-1:

Occurs mostly in the cytoplasm Fatty acid synthesis(B)

A methylene group is converted to a keto group Neither process (C)

4-step reaction cycle is condensation, reduction, dehydration, reduction Fatty acid synthesis(B)

Generates FADH2 Fatty acid degradation(A)

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