Sapling Learning Low concentrations of warfarin near the detection limit gave th

Question

Sapling Learning Low concentrations of warfarin near the detection limit gave the following dimensionless inst readings: 180.3, 151.7, 137.3, 149.3, 194.3, 1, 198 and a reading of 51.9. The slope of the calibration curve is 2.26 x10p M-1. Estimate the signal and concentration detection limits and the lower limit of quantitation for warfarin. Number 142.31 Signal Detection Limit: Number Concentration Detection Limit: click to edit Number Lower Limit of Quantitation L o Previous Check Answer 0Next Ext

Explanation / Answer

standard deviation

mean of ten values given = 161.24

standard deviation = sq.rt.((x-mean)^2/10)

= sq.rt.[(363.284 + 91.0116 + 573.1236 + 142.5636 + 1092.9636 + 683.2996 + 1358.66 + 220.82 + 2656.37 + 370.95)/10]

= 27.483

So,

DL = 3 x 27.483 = 82.449

Limit of concentration = 51.9 + 3 x 27.483 = 134.349

lower limit of quantification = 51.9 + 10 x 27.483 = 326.73

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