11. (10 pts) Match the terms (a-j) with the descriptions (1-10) a) Tertiary stru

Question

11. (10 pts) Match the terms (a-j) with the descriptions (1-10) a) Tertiary structure 7. Compact regions that 1. Basic component of may be connected by flexible segment of polypeptide chain quaternary structure 3. Structure characterized by dynamic hydropho- 4. Proteins that in whole or b) Supersecondary struc- 2. An energy landscape ture_ 8. Refers to the arrange c Domain d) Subunit e) Quaternary structure ment of subunits and the nature of their interactions bic interactions in part lack discrete three-dimensional 9. Cause of spongiform f) Folding funnel g) Molten globule nvetamorphc proteinacid residues that are far proteins structure under physi- encephalopathies 10. Combinations of ological conditions secondary structure present in many 5. Refers to the spatial arrangement of amino apart in the sequence ensemble of structures ) Intrinsically unstruc- 6. Proteins that exist in an tured protein of approximately equal j) Prion energy that are in equilibrium

Explanation / Answer

Solution:

a.) Tertiary structure: Option 5. Refers to the spatial arrangement of the amino acid residues that are far apart in the sequence.

b.) Super secondary structure: Option 10. Combinations of secondary structures are present in many proteins.

c.) Domain: Option 7. Compact regions that may be connected by a flexible segment of a polypeptide chain.

d.) Subunit: Option 1. Basic component of a quaternary structure.

e.) Quaternary structure: Option 8. Refers to the arrangement of subunits and the nature of their interactions.

f.) Folding funnel : Option 2. An energy landscape

g.) Molten globule: Option 3. Structure characterised by dynamic hydrophobic interactions.

h.) Metamorphic protein : Option 6. Proteins that exist in an ensemble of structures of approximately equal energy that are in equilibrium

j). Prion: Option 9. Cause of spongiform encephalopathies

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