10. Sulbactam i is not a penicillin antibiotic: however, it can greatly increase
ID: 1085329 • Letter: 1
Question
10. Sulbactam i is not a penicillin antibiotic: however, it can greatly increase the effects of ampicillin. This interaction can be called synergism. A. True 11. Is marijuana an FDA- licensed drug to treat PTSD: B. False A: True B. False Figure 1 Left: endogenous ligand A at receptor X. Middle: The dotted lines are non-covalent interactions between A and the binding site on receptor X (green cartoon). The atoms and functional groups in X are points at which the receptor specifically binds a ligand. Right the binding of synthetic ligand B at X. Based on figure 1 above, determine if the following statements (Q12-14) are TRUE (a) or FALSE (b). 12. The affinity of ligand A for receptor X is greater than ligand 13. The efficacy of ligand A at receptor X is greater than ligand 8 14. The KD for ligand A is greater than ligand 15. Following continuous exposure of a receptor to a drug, the receptor can become a. desensitized b. downregulated c. tolerant. d. All of the above Figure 2. Efficacy curve of drugs A-E. Determine if the following statements (Q16-21) are (A) TRUE or 16. Drug A is an agonist 17. Drug C is an antagonist? 18. Which of the above is a partial agonist? (B) FALSE. s0 TWMTT19. The EC50 of drug B is less than 0.01 ng/ml 0.001 0.01 0.11 0 100 Drugl (ng/m) 20. Combining Drug A and drug D will led to a response that is greater than both drugs sing 21 Combining Drug A with increasing doses of drug E will lead to a new curve that is to curve A (assume that both drug bind noncovalently to the receptor site)Explanation / Answer
A10. Synergists are used to enhance the effects of drugs. When a drug's effect is increased, it is called synergistic effect and the term is synergism. Here, sulbactam increases the effect of ampicillin, hence, the statement is TRUE.
So, TRUE
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