The following reactions can be coupled to give alanine and oxaloacetate: glutama

Question

The following reactions can be coupled to give alanine and oxaloacetate: glutamate + pyruvate ketoglutarate + alanine delta G degree = - 1004 J/mol at 37 degree C glutamate + oxaloacctate ketoglutarate + aspartate delta G degree = -4812 J/mol at 37 degree C What is the deltaGdegree for the following reaction? pyruvate + aspartate alanine + oxaloacetate In the cytoplasm of a certain cell, the components are at the following concentrations: pyruvate = 10mM. aspartate = 10mM. alanine = 0.1 mM. and oxaloacctate = 10 muM. Calculate the free energy change for the reaction of part (a) under these conditions. What conclusion can you reach about the direction of this reaction under cytoplasmic conditions?

Explanation / Answer

a) flip the second equation so its G will be 4812 J/mol

add the first and second equations up

This will yield the equation asked about in part a

4812 - 1004 = 3808 J/mol = G

b) G = G0 + RT ln Q

G = 3808 + 8.3145(37+273) ln ((0.1E-3)(10E-6)/(10E-3)^2) = -25866.6 J/mol = -25.9 kJ/mol

c) The reaction is thermodynamically and energetically favorable under cytoplasmic conditions. The reaction is spontaneous in proceeding fourth under such conditions

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