3. Discuss the evidence for the biological basis of schizophrenia and schizophre

Question

3. Discuss the evidence for the biological basis of schizophrenia and schizophrenia-spectrum disorders (Be sure to provide at least 3 separate lines of evidence). Does Schizophrenia, in terms of its biological features, differ from other disorders that also include symptoms of neurocognitive disorders? If so, in what ways? How has our greater understanding of the biological underpinnings of schizophrenia influenced the relative importance placed on psychosocial factors to the development and trajectory of the disorder? 101

Explanation / Answer

The dopamine hypothesis suggest that excess of dopamine in certain regions of the brain is linked to schizophrenia. The mesolimbic pathway is associated with the positive symptoms of schizophrenia, such as hallucinations and delusions, and the mesocortical pathway may be responsible for the negative symptoms, such as social withdrawal and anhedonia. The brain volume of those suffering from schizophrenia, especially in the gray matter area have seen to be reduced. Schizophrenia has a genetic basis, twin studies have shown high concordance in monozygotic twins, and a person is more at risk when he/she is more closely related to person suffering from schizophrenia.

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