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pdate To keep up-to-date with security updates, fixes, and improvements, choose Check for Updates 5) Question 5 (5 pt) You are characterizing the firing rate of a neuron by continuously injecting different amounts of current into the cell. You plot the results Firing Rate vs. Simulating Current 5-50 50 Injected Curent (pA) a. (1 pt) From this data, what would you conclude is the duration of the absolute refractory period of the neuron? Briefly explain your thinking. b. (2 pts) Briefly explain (1-2 sentence) the difference in the mechanisms underlying these two types of refractory periods.

Explanation / Answer

Ans 1...absolute refractory period is the duration in which a cell can not be depolarised what ever amount of stimulation is given.in the given graph the gap between the two dots on vertical line defines that time duration which is approximately 50 Hz

Time=1/50=0.02 seconds

Is the absolute refractory period

Ans 2... Mechanism

Absolute refractory period...in this period the cell is in the depilarising stage .all the Na channels are open and Na ions are being used up.so whatever be the stimulus given,no further amount of Na channel can open so no depolarisation of cell can occur

Relative refractory period...in this period the cell is in repolarising stage.K channel are open and Na channel are closed.so if a stimulus more that the potential at that point of time is given may open more Na channel so a cell can depolarise again.

Ans 3..We must prevent the excessive firing rate.so the most effective drug we can use here are Na channel blocker at a specific dose which blocks only some and not all the Na channel

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