Please help me, I am deeply confused in this class and trying so hard to underst

Question

Please help me, I am deeply confused in this class and trying so hard to understand. Please give detailed answers. I know some of these might be confusing but your help will really help me learn. The teacher requires very very detailed answers and he gives nearly no (and I mean literally nearly zero) partial credit so I'm dying here. Thank you sooooooo much, you have no idea.

Also, I am nearly leaglly blind and I am dyslexic so if you could please write clear it would help so much. I just want to learn like everyone else. SUPER SUPER THANK YOU

The following represent two transmembrane proteins within the plasma membrane ofa eukaryotic cell 3. (3 pts total) The region that transverses the membrane is a single alpha helix. Which of the following images best represents the arrangement of the amino acids in this portion of the protein? The black line represents the protein backbone and blue circles represent R groups. Smaller circles are used to indicate R groups farther down the chain. [1 pt] A. B. List three amino acids you are likely to find in this region of the helix. [1 pt] C. What role(s) do these amino acids play in stabilizing the alpha helix in this context? [1 pt]

Explanation / Answer

A) C.

Given the region that transverse the transmembrane membrane is a alpha helix, a rigid rod like structure that forms when a polypeptide chain twists into a helical conformation. In this secondary structure, intrachain hydrogen bonds form between the N-H group of each amino acids and the carbonyl group of the amino acid four residues away. The side chains, R groups, extend outward from the helix

B) Glycine provides more conformational flexibilty than other amino acids, so occurs infrequently. Positively charged amino acids are often found three residues away from negatively charged amino acids, permitting the formation of an ion pair. Two aromatic amino acid residues are often similarly spaced, resulting in a hydrophobic interaction.

c) The partial positive and negative charges of the helix dipole reside on the peptide amino and carbonyl groups near the amino-terminal and carboxyl-terminal ends, respectively. Therefore, negatively charged amino acids
are found near the amino terminus of the helical segment, where they have a stabilizing interaction with the positive charge of the helix dipole.

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