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Questions 22 through 25 are based on the DNA repair mechanisms listed. For the q

ID: 133671 • Letter: Q

Question

Questions 22 through 25 are based on the DNA repair mechanisms listed. For the questions that follow, pick the appropriate mechanism(s) that applies. a. Base excision repair b. Nucleotide excision repair d. Non-homologous end-joining e. None of the above Question 22. Double stranded DNA breaks, made by Spol1, are chewed-back by exonucleases A protein complex, comprising PKes, KUS0, and KU70, then bring non-homologous chromosome ends together and joins them Question 23, MutS and Mutl. scan the DNA for errors. Upon finding errors, Mutit is recruited scan the DNA for crrors. Upon finding emors nearest adenine nucleotide with a methyl group. This methyl tag signals to the cell and 'tags' the is a mismatch in the complementary base pairing of the strands of DNA. Question 24. DNA Glycosylase removes uracil, thereby leaving an AP site. An AP endonuclease cuts the DNA backbone thereby making a nick. Exonuclease then remove nearby nucleotides, thus creating a gap. in replication, ligase seals the nick. DNA polymerase synthesizes new DNA to fill the gap and like Question 25. UVTA and B scan DNA for distortions such as thymine dimers. Upon finding distortions, UvrB and C nick around the distortion and a helicase removes the fragment that is fla nked by the nicks, thereby creating a gap. DNA polymerase synthesizes new DNA to fill the gap and like in replication, ligase seals the nick EXTRA credit (from exam 1) ribosome mRNA D 11 Question 8. Where is the 3' end of the newly synthesized mRNA strand?

Explanation / Answer

Please find the answers below:

The DNA repair mechanisms are highly specific in nature and require a unique set of moleuces and proteins to be present. Based upon the nature of DNA damage, a unique type of repair mechanism is conducted by the cells. These repair mechanisms can be enlisted as below:

Answer 22: Methyl-directed mismatch repair mechanism

Answer 23: Base-excision repair mechanism

Answer 24: Base-excision repair mechanism

Answer 25: Nucleotide excision repair mechanism