12. (8 pts) S cherer-lobes (S) is an autosomal dominant trait that leads to extr
ID: 134097 • Letter: 1
Question
12. (8 pts) S cherer-lobes (S) is an autosomal dominant trait that leads to extremely long, low-hanging gabeormal earlobes (s) is recessive to the Scherer-lobes allele. In a sample of 1000 people in ueastern Indiana (where Dr. Scherer grew up), 132 individuals had Scherer-lobes and 868 arlobes ( uals had normal earlobes. Assuming H-Ww conditions apply, calculate the frequencies of each allele (please round your calculations/answers to 2 decimal places). f (S allele)1 What would be the frequency of heterozygotes in this p decimal places)? opulation (please roundyour answer (m) 3.10(ooo) D068 hat would be the frequency of homozygous dominant individuals in this population (please round your answer to 4 decimal places)?Explanation / Answer
Total number of samples= 1000
Number of people with Scherer-lobes, dominant allele= 132, The genotype can be SS (homozygous) or Ss (heterozygous)
The genotype frequency of SS + Ss = 132 / 1000 = 0.132
Number of people with normal ear lobe (q), recessive allele (ss, homozygous) = 868
Genotype frequency of ss = 868 / 1000 = 0.868 = q2
q= frequnecy of allele s , f(s) =(square root of 0.868)=0.9
According to Hardy-Weinberg equation, (p+q)2 = p2 + q2 + 2pq; p+q=1
p =frequcncy of allele S , f(S) = 1-q = 1-0.9 = 0.1
p2 = frequency of homozygous dominant , f(SS) = 0.1 x 0.1 = 0.01
Frequency of heterozygotes, f(Ss) = 2pq = 2x0.9x0.1 = 0.18
{Note: if the number of Ss was given, the frequency was able to find by
Allele frequency of p = [2 X observed SS + observed Ss] / [2Xobserved SS+observed Ss+observed ss]}
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