For each of the following sentences, fill in the blanks with the best word or ph

Question

For each of the following sentences, fill in the blanks with the best word or phrase selected from the list below. Not all words or phrases will be used; each word or phrase can be used more than once. (2 point each; 30 points total) centrosomes G2 kinases Interphase ubiquitin G0 prophase mitogens prometaphase telophase metaphase p53 cytokinesis Mitosis proteasome G1 phosphatases Cdc25 amino acid phosphate carbon p21 glycogen Rb p19 Cdk2 nucleus cyclin Cyclin B centromere Wee1 The cell cycle consist of four phases. The phase between M phase and the next M phase and includes three phases of the cell cycle DNA is replicated in S in the cell cycle is and phase. Different cyclin-Cdk complexes control the cell's progression through the cell cycle. M-Cdks activity regulates the cell cycle entry into M phase. The M cyclin- Cdk complex can be inactivated by Wee1 if DNA has not been replicated or if DNA has been damaged. Wee1 is a that phosphorylates Cdk, inactivating the M cyclin-Cdk complex. When DNA damage has been repaired, the inhibitory phosphate on Cdk can be removed by phosphates are Proteins that remove During M phase, DNA is segregated (separated) to opposite poles of the cell. After the DNA has been segregated to opposite poles, which occurs during Cunap hase in mitosis, the anaphase promoting complex (APC) marks S and M cyclins for destruction by addition of a chain to the cyclin. Cyclins marked this way are targeted to the where they are degraded When the cell is not preparing for division, it is in a resting state or When mammalian cel l needs to exit this resting state and divide, they are stimulated by extracellular signals called DNA damage can arrest the cell cycle in G1 by activating the tumor suppressor protein This activated protein stimulates the transcription of the Cdk inhibitor protein

Explanation / Answer

The cell cycle consist of four phases. The phase between M phase and the next M phase in the cell cycle is interphase and includes three phases of the cell cycle G1 , S , and G2 . DNA is replicated in S phase.

Different cycin-cdk complexes controls the cells progression through cell cycle. M-cdks activity regulates the cell cycle entry into M phase. The M cyclin-cdk complex can be inactivated by wee1 if DNA has not been replicated or if DNA is has been damaged. Wee1 is a kinases that phosphorylates Cdk, inactivating the M cyclin-cdk complex. When DNA damage has been repaired, the inhibitory phosphate on Cdk can be removed by phosphatases . Proteins that remove phoshatases are cdc25 .

During M phase, DNA is segregated ( separated) to opposite pole of the cell. After the DNA has been segregated to opposite poles, which occurs during prometaphase in mitosis, the anaphase promoting complex (APC) marks S and M cycilns for destruction by addition of a ubiquitin chain to cyclin. Cyclin marked this way are targated to the proteosome when they are degraded.

When the cell is not preparing for division, it is in a resting state or G0 . When mammalian cell needs to exit this resting state and divide, they are stimulated by extracellular signals called mitogens .

DNA damage can arrest the cell cycle in G1 activating the tumor suppressor protein p53 . This activated protein stimulates transcription of the CdK inhibitor protein p21 .

Related Questions

Navigate

• Browse (All)
• Browse F
• Subjects

---

---

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.