Questions 14 and 15 are based on the following. (1 mark for each blank) Base ana

Question

Questions 14 and 15 are based on the following. (1 mark for each blank) Base analogs are a class of chemical mutagens that have a similar chemical structure to a normal nucleotide such that DNA polymerase cannot differentiate them. The base analog, 5'-bromouracil, competes with the normal base thymine during DNA replication and results in point mutations (i.e. base substitutions) Normal nucleotide base Analog Br Thymine 5'-bromouracil Normally, 5-bromouracil can pair with adenine just like thymine, but it possible for it to mispair with guanine Br OH-N Br Sugar Sugar 5-bromouracil 5-bromouracil (keto form) Adenine Guanine (onol form) Normal pairing Mispairing

Explanation / Answer

after second replication event thymine(T)on the top strand has changed to C and the adenine on the bottom strand has changed to G

this is example of Transition

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