ookmarks Window Help moodle.amnh.org s in Adult Care... Error Course: Genetics,

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ookmarks Window Help moodle.amnh.org s in Adult Care... Error Course: Genetics, Geno. Western Governors Od. Insulin dosages should be given less frequently because the drug will remain bound to receptors longer. What would be the patients response to a normal drug dose that because of a genetic variation in an enzyme that prepares the drug for elimination results in a blood drug level that is below the minimum effective concentration (MEC)? Select one: a. Drug entry exceeds drug elimination b. The intended response fails to be produced. C. The risk for toxic side effects is increased. d. The drug's duration of action is longer than expected. A woman whose sister tested positive for a specific mutation in the BRCA1 gene which increases the risk for breast and ovarian cancer, is found not to have that mutation but does have a mutation of unknown significance near the known mutation site. How should this woman be counseled? stion Select one: 0 a. She should be informed that she does not have the specific mutation but that because another mutation is present she should be vigilant about screening b. She should be informed that her risk for breast cancer is greater than the general population but not as great as her sister's risk. c. She should be informed that because she does not have the mutation, her risk for breast cancer is not greater than that of the general population.

Explanation / Answer

Since the blood drug level is below the minimum effective concentration (MEC);

b. The intended response fails to be produced. (As the concentration of drug below MEC is said to be in the sub-therapeutic level).

The women should be counseled;

a. She should be informed that she does not have the specific mutation but that because of another mutation is present she should be vigilant about screening.

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