This problem refers to the MN and ABO loci mentioned in class. It also refers to

Question

This problem refers to the MN and ABO loci mentioned in class. It also refers to the Rh locus, which is responsible for the positive/negative part of the blood type. The Rh+ allele is dominant to the Rh- allele at this locus. Select all couples who could be the parents of a child with phenotype MN, A- based on the phenotypes at these three loci. If none of these couples could be the parents of this child, select "None of These".

Select one or more:

Mother Type M, A+ and Father Type N, B-

Mother Type MN, AB- and Father Type M, O-

Mother Type MN, B+ and Father Type N, O+

Mother Type MN, O+ and Father Type MN, A-

None of These

Explanation / Answer

The MNS blood group is co-dominant i.e. both M and N are expressed in the offsprings. In the ABO blood group system both A and B alleles are codominant and can be expressed simultaneously and O/Io is recessive. Parents with blood group A and B can be heterozygous. In Rh system Rh+ is dominant over Rh-. The phenotype of the offspring should be MN, A-

Therefore, based on the data given above, we can coclude that:

Option 1(Mother Type M, A+ and Father Type N, B-)

Option 2 (Mother Type MN, AB- and Father Type M, O-)

option 4 (Mother Type MN, O+ and Father Type MN, A-) are the correct options.

Mother Type MN, B+ and Father Type MN, O+ is not the option since the child would be either B+/- or O+/-.

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