*Please answer the question in bold* We are making a mutation in a protein and w

Question

*Please answer the question in bold*

We are making a mutation in a protein and want to preserve the activity. If there is an active site aspartic acid, what conservative substitution might work?

42. In the same protein for the above question, we can compare several sites. If we look at the same protein from 10 different organisms and find N, R, K, Y, A, L, L, I, K, P at that site, what might you be able to say about this site?

a. The site is not conserved and highly variable.

b. The site is modestly conserved.

c. The site is highly conserved.

d. The site is critical for biological function.

The correct answer is A, The site is not conserved and highly variable.

Please explain why.

Explanation / Answer

You are right that the answer is A that the site is not conserved and highly variable because the Aspartic acid is a negatively charged aminoacid and to substitute it in a conserved manner the substituted amino acid must contain the negative charge as similar to Aspartic acid. The amino acid sunstituted in different species are not negativey charged and mmost of them are positively cahrged and polar amino acid.

Related Questions

Navigate

• Browse (All)
• Browse #
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.