You have landed a great new job at a pharmaceutical company. Your job is to deve

Question

You have landed a great new job at a pharmaceutical company.  Your job is to develop antibiotics.  A key concept in antimicrobial drug development is “selective toxicity” meaning the antimicrobial compound must be more toxic to the microbe than the host.  The less toxic it is to the host the more useful the antimicrobial agent is.  You have developed a new compound and have tested its ability to kill (cause mortality) in 3 organisms.  Please use the data below to answer the following questions.  

For each of the possible mechanisms listed below indicate if this new data changes whether this could be the mechanism of action for this antibiotic, and please explain your answer.

a. Inhibiting endoplasmic reticulum formation

b. Inhibiting the linking of NAG directly to NAM in peptidoglcan.

120 100 80 Clostridium difficile Amoeba proteus 60 Halobacterium salinarum 40 20 0 mM 10 mM 20 mM 30 mM 40 mM 50 mM 60 mM 70 mM 80 mM 90 mM 100 10 20 130 mM mM mM mM Antibiotic Concentration

Explanation / Answer

Now come to the point :--

Antibiotic:-- Chemicals produced by a microbe to kill others microbes called antibiotic. In short, if it kills bacteria can speak a antibiotic.

Now how it works :--

We will understand from two points which has been given us;::----

A). Now if antibiotic is applied on microbe now what are ways by which it can show its effect.

**Now take the example of impairments in ER in bacterium.

Now we know that ER helps in formation of various protein so protein transfer from ER to plasma membrane gets altered. So plasma membrane will not form and bacteria ultemately ends.

2). Yes in proteins, as we know that this is a polypeptide but polypeptide has linkings in them but here linkings get altered .

This NAG if doesn't link to the NAM then cell wall murein can not form and bacterium will end.

NAG and NAM are the components of Murein in Bacteria.

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