B. Exon 3, which is the intracellular domain, contains 11 \'elastic repeat units

Question

B. Exon 3, which is the intracellular domain, contains 11 'elastic repeat units' (blue disks) which are 13-mer repeats of this amino acid sequence: GYSGGRPGGODLG. These segments are also attached by amino acids of opposite polarity, but the connecting segments are larger than they were in exon 1 (5-10aa). Additionally, there is a large block of amino acids with opposite polarity to the 13-mer in the center exon 3, as indicated by the larger blue space in Figure 1. Exon 3 is able to form a micelle- like structure in water, as shown below. The teal blue disks are the 13-mer and the dark blue lines are the connecting regions (ignore the lines and letters on the outside). Micellar Structure How does the primary sequence of this exon relate to its ability to form micelles?

Explanation / Answer

Micelle are the type of lipids molecules that are formed as a result of ampiphatic property of fatty acid. As, given in this question , there are two exon. Exon 3 code for peptide sequence which is 13 mer repeating units. Exon 1 code for the peptide which is having opposite polarity . Hence, peptide coded by exon 3 will be hydrophobic and peptide coded by exon 1 which is hydrophilic. This ultimately lead to the amphiphatic nature means both hydrophobic and hydrophilic group in one molecule which is a criteria for formation of Micelle.

Hence, the primary sequence of exon that ultimately code for two types of peptides which are hydrophobic and hydrophilic relate it's ability to form Michelle's.

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