This is my third time posting this question on chegg, please consider solving it

Question

This is my third time posting this question on chegg, please consider solving it only if you're confident with the material. Much appreciated

1. aristaless-3 [a3] autosomal mutant Drosophila melanogaster flies have no Aristae (antennae) Female flies that are homozygous for this mutation are sterile. Another autosomal mutation, aristapedia [ap] produces flies that have abnormal development of antennae, where they develop into deformed legs. Aristapedia is homozygous lethal. If you were to design a vial such that it contained 1 homozygous purebred wild type [wt] female, 1 heterozygous aristaless-3 and aristapedia mutant male, 1 homozygous aristaless-3 (homozygous wildtype at the other locus) female, and 1 homozygous aristaless-3 male (homozygous wildtype at the other locus), (a) what is the phenotype ratio expected in this vial in the next generation? (b) If you had a vial with a heterozygous aristaless-3 and aristapedia mutant male, and one heterozygous aristaless-3 and aristapedia mutant female, what is the expected phenotype ratio in the vial in the surviving offspring in the next generation? wt 3 Figure 1 af3 versus wt (eft), and ap versus wt (right. Image courtesy http://agslab.com/phenotypes wt

Explanation / Answer

ANSWER (a): In the next generation of flies reporduced in the vial, 2 heterozygous aristaless-3 and artistapedia mutant female, 2 wild type male, 2 heterozygous aristaless-3 mutant female and two heterozygous aristaless-3 mutant male would be born. Since the homozygous mutation of aristaless-3 renders the female flies sterile, so the female homozygous aristaless-3 will not further the generation. So the phenotypic ratio is 1:1:1:1 for heterozygous aristaless-3 and artistapedia mutant female, wild type male, heterozygous aristaless-3 mutant female and heterozygous aristaless-3 mutant male.

ANSWER (b): In this vial, the next generation would be either in the ratio of 1:1:1 for heterozygous aristaless-3 and artistapedia mutant female, one wild type male or female, and one heterozygous aristaless-3 and artistapedia mutant male. The homozygousaristaless-3 and artistapedia mutant female or male in this generation having the homozygous mutation artistapedia would prove to be fatal.

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