A biological membrane can be thought of as a proteinlipid «sandwich» consisting

Question

A biological membrane can be thought of as a proteinlipid «sandwich» consisting of an exclusively phospholipid interior coated on both sides with thin layers of protein. Drag the terms on the left to the appropriate blanks on the right to complete the sentences. terms will be used. fibrillar lipid interior globular outer protein layer electron light Consistent with early parallel electron-dense lines (thought to be the (thought to be the microscopy in wh ; disproved by the o by the structures located within the membran two three

Explanation / Answer

Consistent with early electron microscopy in which membranes appeared as two parallel electron dense lines thought to be the outer protein layer separated by unstained space though to be the lipid interior disproved by the demonstration that membrane proteins are globular structures located within the membrane, not just on the surface.

In the late 1950s. After staining with heavy metal labels, Sjöstrand et al. noted two thin dark bands separated by a light region, which they incorrectly interpreted as a single molecular layer of protein. A more accurate interpretation was made by J. David Robertson, who determined that the dark electron-dense bands were the headgroups and associated proteins of two apposed lipid monolayers. Later on this conclusion led him to formulate "unit membrane concept'.

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