Question 5 Shown on the right is the crystal structure of Pelota, an mRNA qualit

Question

Question 5 Shown on the right is the crystal structure of Pelota, an mRNA quality control factor that binds the ribosome when the ribosome is stalled (for example when elongation is blocked by strong secondary structure in the mRNA). Based on the structure shown and what was covered in class, answer the following questions A- What RNA molecule does this factor resemble? B- Based on answer, where do you think this protein binds on the ribosome? Explain briefly C.) Pelota is also similar to which protein studied in class? (name one)

Explanation / Answer

Please find the answers below:

Answer 1: According to the information and the descriptive image, it can be clearly seen that the RNA molecule strongly resembles a tRNA.

Answer 2: It is a very well known fact that binding of tRNA to the ribosome at the codon site plays a critical role in gene expression and translation. Hence, this tRNA must bind near the small ribosomal subunit at the codon-anti-codon interface.

Answer 3: The tRNA-containing protein can be similar to many biological proteins such as amanatin found in fungus Amanita, which prevents translation.

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