3. Assume that alleles A, B, C, D, and E are associated with predisposition to p

Q: 3. Assume that alleles A, B, C, D, and E are associated with predisposition to p

Answer By applying sum rule a) for AABBccddEE 1+1 + 3+3 +0+0 + 0+0 + 1.25+1.25 =10.5% b) AABbccDDee 1+1 + 3+0 + 0+0 + 0.75+0.75 + 0+0= 6.5% c) AabbCcDdEe 1+0 + 0+0 + 1.5+0 + 0.75+0 + 1.25+0 =4.5%

ID: 144762 • Letter: 3

Question

3. Assume that alleles A, B, C, D, and E are associated with predisposition to pancreatic cancer. Individua enotypes mate: AABbccDdEe X AaBbCcDdee For each of the cases below, calculate the probability of producing a child with the given genotype, then assess the predisposition of that child to cancer based on the following Every allele A adds 1% to the cancer risk, every allele B adds 396, every allele C adds 1.5%, every allele D adds 0.75%, and every allele E adds 1.25%. Individuals with none of the allele have a risk of 1.5%. Is with the following & a) AABBccddEE b) AABbccDDee c) AabbCcDdEe

Explanation / Answer

Answer

By applying sum rule

a) for AABBccddEE

1+1 + 3+3 +0+0 + 0+0 + 1.25+1.25 =10.5%

b) AABbccDDee

1+1 + 3+0 + 0+0 + 0.75+0.75 + 0+0= 6.5%

c) AabbCcDdEe

1+0 + 0+0 + 1.5+0 + 0.75+0 + 1.25+0 =4.5%

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3. Assume that alleles A, B, C, D, and E are associated with predisposition to p

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