Please help me with these two biology questions: Why would an antibiotic at the

Question

Please help me with these two biology questions:

Why would an antibiotic at the same concentration be more active against bacteria in water than in serum or plasma? (Activity is measured in a test tube)


A.
activity of the antibiotic is increased in water.

B.
due to drug-protein interaction in serum

C.
the antibiotic is more stable in water

D.
all of the above

E.
none of the above


If you want to increase the blood concentration of a drug A, you can perform which of the following procedures:


A.
Inhibit Drug A metabolism with Drug B

B.
Enhance Drug A reabsorption from renal proximal tubule by changing ionization of Drug A with Drug B

C.
Allow competition of Drug B with Drug A for active renal secretion processes

D.
Increase the binding of Drug A to serum albumin

E.
All of the above

Explanation / Answer

1)Binding to plasma proteins plays a major role in drug therapy because it affects pharmacokinetics and pharmacodynamics of drugs.Protein binding of antibiotics may affect the efficacy of therapy in following ways-

A)Only the non-protein-bound fraction of a drug in plasma can penetrate into and make space in the extravascular space. Penetration into the extravascular space is very important for antimicrobial therapy, as the majority of bacterial and fungal infections occur in the extravascular space like interstitial fluid of tissues .

B)Protein binding also affects drug clearance by tubular secretion or hepatic metabolism, high PB is associated with lowered drug elimination and it negatively correlates with glomerular filtration, due to negatively charged protein repulse negatively charged glomerular membrane so only the free drug is filtered.

2)If you want to increase the blood concentration of a drug A, We can perform following actions


A.Inhibit Drug A metabolism with Drug B

B.Enhance Drug A reabsorption from renal proximal tubule by changing ionization of Drug A with Drug B

C.Allow competition of Drug B with Drug A for active renal secretion processes

D.Increase the binding of Drug A to serum albumin

so answer is all of the above

Related Questions

Navigate

• Browse (All)
• Browse P
• Subjects

Integrity-first tutoring: explanations and feedback only — we do not complete graded work. Learn more.