ooo Sprint 12:10 AM 43 Exit Answer the following multiple choice and free respon

Question

ooo Sprint 12:10 AM 43 Exit Answer the following multiple choice and free response questions. For the free response questions answer either using the text box or upload a PDF, DocX, or picture (JPG, GIF, TIFF) file where appropriate. 1 Binding of O2 to a O2-binding site on hemoglobin promotes conversion between the T- and R-states of hemoglobin. lon pairs are electrostatic interactions between positively and negatively charged amino acids. For hemoglobin, some of these ion pairs stabilize the T- state of hemoglobin. Based on what you know about the protonation states of amino acids in response to the changes in pH, how will the equilibrium between the T- and R-states of hemoglobin be affected by changes in pH? om showing ahigty shematic traing dfte structures Here the tanscarent so that nteractions at the

Explanation / Answer

1) An increase in pH unit will destabilize the T state shifting the equilibrium towards the R state.

2) Higher proton concentration corresponds to lower pH, this means that lower the pH, T state of heamoglobin will more stable.

3) 1

4) The T state has less of an affinity for oxygen than R state. One of the salt bridge is formed by the interaction between Beta Histidine146

5) 6.0

6) The pH is a measure of the concentration of hydrogen ions in an aqueous solution. While pKa is related but more specific, in that it helps you predict what at specific pH.

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