47. Which of the following is TRUE? enzymes are rarely important in the regulati
ID: 147649 • Letter: 4
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47. Which of the following is TRUE? enzymes are rarely important in the regulation c enzymes. concen ichaelis-Menten kinetics describe the reactions of alloste of enzyme activity C. osteric enzymes have a hyperbolic plot of reaction rate vs Allosteric enzymes are composed of a single polypeptide chain d. 48. Inhibitors can have the following effects on enzyme kinetics: a. Increase the KM value. b. Decrease the value for V c. Interfere with substrate binding. d. Decrease the Ku value. e. All of these are correct 49. Assuming the oligopeptide Ala-Leu-Ala-Thr-Ala-His-Glu-Leu- bd to the amide Lys-Ser forms one continuous a-helix, the carbonyl oxygen of the first Leu res nitrogen of a. leucine. b. glutamate. orthe t rs e. serine c. alanine. d. histidine. 50. Which of the following best defines a domain? a. A independently folded re A supersecondary structure. sion, often shared by proteins, without a specific function. b. c. A double-layered arrangement formed so that the polar groups face the s environment. d. e. environment, while the nonpolar regions are kept away from ths An unfolded region of a protein. aqueous environment. A independently folded region, often shared by proteins, that has a fic function. 51. The amino acid sequence of a polypeptide is referred to as itsstructure. 5° e. b. 2 c. 3 d. 4° 52. An enzyme displays sigmoidal behavior when initial velocity is plotted against substrate concentration. With increasing concentrations of compound A' added, the kinetics curve is displaced to the left. Compound 'A' is most likely: a. a positive allosteric effector. b. a competitive inhibitor. c. a negative allosteric effector. d. a noncompetitive inhibitor e. an irreversible inhibitor. 53. In the p-pleated sheet conformation there are hydrogen bonds perpendicular to the direction of the polypeptide chain the polypeptide chain is almost fully extended. the polypeptide chains may be hydrogen bonded together in a parallel or antipa orientation the R groups are above and below the plane of the sheet all of these a. b. c. d. e.Explanation / Answer
47. Answer is D: None of these are true.
48. Asnwer is e. All of these are true.
49. Answer is d. Histidine.
Because a hydrogen bond forms between the carbonyl oxygen of the nth amino acid residue and the -NH group of the (n + 4)th amino acid residue. Leu in the given chain is in 2nd position therefore amino acid at 6th position (His) will form hydrogen bond with 2nd position Leu.
50. Answer is e. A independently folded region, often shared by proteins, that has a specific function.
51. Answer is a. 1o
The primary structure of polypeptides and proteins is the sequence of amino acids in the polypeptide chain.
52. Answer is a. A positive allosteric effector.
53. Answer is e. All of these.
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