42. Second messenger cAMP is produced by a. Phospholipase C b. G protein a. c. a

Question

42. Second messenger cAMP is produced by a. Phospholipase C b. G protein a. c. adenyl cyclase d. protein kinase C e. GTP 43. Activation of G Protein follows the first event of a. binding of GDP to the receptor b. binding of a ligand to a receptor c. binding of ATP to the receptor d. activation of adenyl cyclase e. activation of cyclin dependent kinase 44. Which molecule is not the product of phospholipase C activation ? a. DAG b. CAMP c. IP3 45. What site(s) in the cell is/are the storage of Ca ? a. cytoplasm b. ER c. lysosomes d. nuclei e. peroxisomes 46. Proetin kinase C is activated by a. IP3 b. cAMP c. DAG d. G Protein e. Ca? Match the term with a definition: a. MAPK b. PKC c. RTK d. Ras e. calmodulin 47-50. 47. Calcium binding protein regulating activity of other enzymes 48. Protein analogous to the G protein activated by Receptor Tyrosine Kinase 49. Enzyme located on the plasma membrane self phosphorylating 50. Kinases activated by a variety of cell proliferating and differentiation-inducing signals

Explanation / Answer

Ans-42

a) Phospolipase-C is membrane associated enzymes which produce two second messenger IP3 and DAG

b) G-protein alpha is sub unit of G-protein coupled receptor

c) Adenyl cyclase is enzyme associated with G protein coupled receptor through cell membrane which produce c-AMP a second messenger from ATP, so correct

e) GTP is energy rich nucleotides like ATP which contain

So c option is correct

Ans-43

Binding of ligand to GPCR change confirmation of this receptor so it is activated which in turn change conformation of G-protein, further lead to displacement of GDP by GTP of Gs alpha subunit. This subunit separate from other two submit and activate addinal cycles which further form second messenger c-AMP.

Show our option d is correct

Ans-44

Phospholipase receptor when bind to Legend generate two second messenger, inositol triphosphate(IP3) and diacylglycerol(DAG).

Show our option B is correct

Ans-45

Endoplasmic reticulum is storage site of calcium for non muscle cell

So our answer b is correct

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